Personal information;
Frank J. Bruggeman
Molecular Cell Physiology & Integrative Bioinformatics
Faculty Earth and Life Sciences (FALW) & BioCentrum Amsterdam
Vrije Universiteit, De Boelelaan 1085, 1081 HV, Amsterdam, The Netherlands
Tel:   +31-20-5987248 (NEW) (at department; at room M262)
      +31-6-41427189 (personal cell phone)
Fax:   +31-20-5987229 (NEW)
Email: frank.bruggeman@falw.vu.nl
WWWW: www.angelfire.com/scifi/frankb

Research (current and plans);
1. modular description of biochemical reaction network on basis of mass
balance description of dynamics (not phenomenological but mechanistic),
2. kinetic modeling of central carbon and energy metabolism including
metabolism, signal transduction, and gene expression in Escherichia coli,
3. robustness of biochemical reaction networks against specific
perturbations as a result of the active regulation by molecular mechanisms;
on the need for robust control of cellular state,
4. dissection of changes in the metabolic state of organisms in terms of
metabolic, transcriptional, and translational phenomena,
5. prediction of transcription network interaction structure of bacteria on
basis of growth capabilities,
6. limits of reaction-diffusion master equation; (a) to PDE and (b) to
reaction master equation and their limits to reaction ODE (e.g. with use
linear noise approximation)
7. control analysis of fluctuations in biochemical reaction networks