Modelling Diabetes WorkGroup

MISSION

The Modelling Diabetes Workgroup is a workgroup within the EU-funded network of Excellence BioSim (http://biosim.fysik.dtu.dk:8080/biosim/). This workgroup aims at developing a whole-body kinetic model of diabetes relevant for experimental studies on diabetes. The workgroup consists of modelleres and experimental biologists (physiologists, biochemists, and cell biologists).

TOPICS

beta cell kinetic model (coupling central carbon and energy metabolism (glycolysis, TCA) ion-channelling induced insulin secretion by exocytotic vesicles)
whole-body modelling: whole-body stoichiometric matrix characterizing mass-flow essential to diabetes with organs as supra-enzymes, input-output kinetic characterization of organs, macrochemical equation for organs
assesment of available kinetic and (whole body) physiological data characterizing reference states to be modelled

MEMBERS

Frances Ashcroft	Oxford, UK	ion-channels beta cells
Patrick Rorsman	Oxford, UK	ion-channels beta cells
Andrei Tarasov	Oxford, UK	islet electrophysiology
Gunnar Cedersund	Linkoping, SE	system identification, modelling
Peter Stralfors	Linkoping, SE	insulin signalling
Sune Dano	Copenhagen, DK	whole body and glycolysis modelling
Mads Madsen	Copenhagen, DK	whole body modelling
Bjorn Quistorf	Copenhagen, DK	physiology, biochemistry
Jeroen Jeneson	Eindhoven, NL	modelling muscle energetics
Peter Hilberts	Eindhoven, NL	modelling muscle energetics
Natal van Riel	Eindhoven, NL	modelling muscle energetics
Anton Wagenmakers	Eindhoven, NL & Birmingham, UK	physiology, biochemistry, diabetes
Pal Westermark	Berlin, GE	beta cell modelling
Morten Gram Pedersen	Copenhagen, DK	synchronization of islet dynamics
Hans Westerhoff	Amsterdam, NL & Manchester, UK	kinetic modelling, physiology
Hans van Beek	Amsterdam, NL	physiology
Frank Bruggeman	Amsterdam, NL & Manchester, UK	kinetic modelling